An atomic-level mechanism for activation of the kinesin molecular motors
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چکیده
منابع مشابه
An atomic-level mechanism for activation of the kinesin molecular motors.
Kinesin cytoskeletal motors convert the energy of ATP hydrolysis into stepping movement along microtubules. A partial model of this process has been derived from crystal structures, which show that movement of the motor domain relative to its major microtubule binding element, the switch II helix, is coupled to docking of kinesin's neck linker element along the motor domain. This docking would ...
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Kinesin motors have been studied extensively both experimentally and theoretically. However, the microscopic mechanism of the processive movement of kinesin is still an open question. In this paper, we propose a hand-over-hand model for the processivity of kinesin, which is based on chemical, mechanical, and electrical couplings. In the model the processive movement does not need to rely on the...
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Carolina Carrasco, Iwan A. T. Schaap, Pedro J. de Pablo, Christoph f. Schmidt 1 Departamento de Física de la Materia Condensada C-III, Universidad Autónoma de Madrid, 28049 Madrid, Spain 2 National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom 3 Physikalisches Institut, Fakultät für Physik, Georg-August-Universität, Friedrich-Hund-Platz 1, 37077 Göttin...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0911208107